Regioselective and Diastereoselective Alkyl-Alkene and Alkene-Alkene Coupling Promoted by Zirconocene and Hafnocene

Article abstract of DOI:10.1021/jo00276a006

The reaction of Cp2Zr(CH2CH2R¹)2 with a monosubstituted terminal alkene (H2C=CHR²) can produce, in a highly regio- and diastereoselective manner, zirconacyclopentane derivatives; the trans-3,4-disubstituted derivatives may be formed to the extents of >98percent in cases where both R¹ and R² are alkyl, while the trans-2-aryl-4-alkyl derivatives may be formed to the extents of >98percent in the coupling between a monoalkyl-substituted olefin and styrene or its derivative.