Bioorganic and Medicinal Chemistry Letters p. 2582 - 2585 (2010)
Update date:2022-08-05
Topics:
Hu, Yueqing
Ho, Maurice K.C.
Chan, King H.
New, David C.
Wong, Yung H.
A series of substituted N-[3-(3-methoxyphenyl)propyl] amides were synthesized and their binding affinities towards human melatonin MT1and MT2receptors were evaluated. It was discovered that a benzyloxyl substituent incorporated at C6 position of the 3-methoxyphenyl ring dramatically enhanced the MT2binding affinity and at the same time decreased MT1binding affinity.
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(2010)Doi:10.3184/030823409X12508790019612
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(2010)Doi:10.1248/bpb.33.725
(2010)Doi:10.1016/j.jorganchem.2010.02.025
(2010)Doi:10.1021/ja102623j
(2010)
