Chemical and pharmaceutical bulletin p. 506 - 508 (1989)
Update date:2022-08-05
Topics:
Ishiguro
Eguchi
Capping is a useful technique to facilitate purification of a crude deprotected peptide in solid-phase peptide synthesis. However, we observed a serious side reaction caused by the Ac2O capping procedure, when it was applied to a synthesis of a peptide containing His. The mechanism of the side reaction was studied.
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