Journal of Heterocyclic Chemistry p. 1283 - 1287 (1995)
Update date:2022-07-30
Topics:
Bhupathy
Conlon
Wells
Nelson
Reider
Rossen
Sager
Volante
Dorsey
Hoffman Jr.
Joseph
McDaniel
A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L-754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from com
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