A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine, a key intermediate for the HIV protease inhibitor, L-754,394

DOI: 10.1002/jhet.5570320431

Source and publish data:

Journal of Heterocyclic Chemistry p. 1283 - 1287 (1995)

Update date:2022-07-30

Topics:

Authors:

Bhupathy

Conlon Conlon

Wells Wells

Nelson Nelson

Reider Reider

Rossen Rossen

Sager Sager

Volante Volante

Dorsey Dorsey

Hoffman Jr.

Joseph Joseph

McDaniel

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Article abstract of DOI:10.1002/jhet.5570320431

A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L-754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from com

Full text of DOI:10.1002/jhet.5570320431

Products guided by the article

Product name:4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester

Cas No:124031-00-1

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