A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine, a key intermediate for the HIV protease inhibitor, L-754,394

DOI: 10.1002/jhet.5570320431

Source and publish data:

Journal of Heterocyclic Chemistry p. 1283 - 1287 (1995)

Update date:2022-07-30

Topics:

Authors:

Bhupathy

Conlon Conlon

Wells Wells

Nelson Nelson

Reider Reider

Rossen Rossen

Sager Sager

Volante Volante

Dorsey Dorsey

Hoffman Jr.

Joseph Joseph

McDaniel

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/jhet.5570320431

A practical synthesis of 5-(chloromethyl)furo[2,3-b]pyridine (10), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L-754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from com

Full text of DOI:10.1002/jhet.5570320431

Products guided by the article

Product name:4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester

Cas No:124031-00-1

R&D Labs maybe for 124031-00-1

Shanghai Massive Chemical Technology Co., Ltd.

website:http://www.massivechem.com/

Contact:+86 21 34943721

Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,
Shanghai Puda Chemical Co.,Ltd

Contact:+86+571+56565965

Address:10F Haiyue Building,Danfeng Road,Binjiang District,Hangzhou,China
JIN TAN CHENG'EN CHEMICAL CO.,LTD.

Contact:86-519-82116250

Address:NO.102，village Dongfang，conomic development zone
MedicalChem(Yancheng)Manuf.Co.,Ltd.

Contact:+86-515-84383366

Address:Touzeng BinHai, YanCheng City, JiangSu Province, China
Xi'an caijing Opto-Electrical Science & Technology Co., LTD

Contact:+86-29-88294447

Address:NO.168 Zhangba Rd. East, Xi'an, P.R.China

Relevant to this article

Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides

Doi:10.1021/jm00164a044
(1990)
N(1)-, N(3)-, and O-alkylation of 5-cyano- 2-methylsulfanyl-4(3h)- pyrimidinone by 4-substituted ω-Bromoacetophenones in the system acetonitrile-K₂CO₃

Doi:10.1007/s10593-010-0444-y
(2009)
Microwave-assisted synthesis, structure, and tunable liquid-crystal properties of 2, 5-diaryl-1, 3, 4-thiadiazole derivatives through peripheral n-alkoxy chains

Doi:10.1002/asia.200800440
(2009)
Stereoselective Addition Reaction of Diethylzinc to Aldehydes, Catalyzed by Cinchona Alkaloids

Doi:10.1021/jo00377a024
(1987)
Low-cost dyes based on methylthiophene for high-performance dye-sensitized solar cells

Doi:10.1016/j.dyepig.2010.03.029
(2010)
Synthesis of naphtho[1,8-bc]pyran derivatives and related compounds through hydroxy group directed C-H bond cleavage under rhodium catalysis

Doi:10.1002/asia.200900639
(2010)

Article Doi