Generation of diverse 2 H-isoindol-1-ylphosphonates via three-component reaction of 2-alkynylbenzaldehyde, aniline, and phosphite

DOI: 10.1021/cc100101a

Source and publish data:

Journal of Combinatorial Chemistry p. 743 - 746 (2010)

Update date:2022-08-04

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Authors:

Yu, Xingxin

Ding, Qiuping

Wu, Jie Wu, Jie

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Article abstract of DOI:10.1021/cc100101a

Diverse 2H-isoindol-1-ylphosphonates as potential HCT-116 inhibitors are easily generated via a FeCl₃ and PdCl₂ cocatalyzed three-component reaction of 2-alkynylbenzaldehyde, aniline, and phosphite. The focused small library is constructed based on parallel diversity-oriented synthesis.

Full text of DOI:10.1021/cc100101a

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