Journal of the Chemical Society. Perkin transactions I p. 2849 - 2858 (1994)
Update date:2022-08-05
Topics:
Nakashima, Hideki
Hirata, Norihiko
Iwamura, Takeru
Yamagiwa, Yoshiro
Kamikawa, Tadao
(2S,3S,4R)-2-<(2'R)-2-Benzoyloxydocosanoylamino>-16-methylheptadecane-1,3,4-triol 3,4-dibenzoate 32, apertially protected ceramide part of a cerebroside from the marine sponge Halichondria japonica, has been synthesized from L-ascorbic acid, and its absolute stereochemistry has been determined.The key steps in the synthesis include the regioselective ring opening of chiral epoxide 5 with a 2-alkyl-2-lithio-1,3-dithiane and the introduction of a hydroxymethylene synthon using Dondoni's protocol to assemble C(1) and C(2) functionality.
View MoreShanghai Bojing Chemical Co., Ltd.
Contact:021-37122233
Address:6F Buildiing 11,No.388,Baifu Road,District Fengxian.Shanghai, China.
WEIFANG RICHEM INTERNATIONAL LTD
Contact:86-536-2222176
Address:weifang,shandong
Contact:86-512-87182055
Address:No.128 Fangzhou Rd, Suzhou Industrial Park, China, 215125, China
Chongqing Rong＆Quan Pharmaceutical Technology Co. , Ltd.
Contact:86-023-65268721
Address:No. 7, Manshanhong Village, Pingdingshan, Shapingba District, Chongqing Province, China
Contact:+44 (0)161 367 9441
Address:
Doi:10.1021/jm00170a017
(1990)Doi:10.1021/ja105121z
(2010)Doi:10.1021/ja00158a079
(1990)Doi:10.1016/0223-5234(89)90111-6
(1989)Doi:10.1016/j.bmc.2010.06.071
(2010)Doi:10.1039/a808293f
(1999)
