Synthesis, spectral analysis, and in vitro microbiological evaluation of ethyl 7,9-diaryl-1, 4-diazaspiro[4.5]dec-9-ene-6-carboxylates as a new class of antibacterial and antifungal agents

Article abstract of DOI:10.1007/s10593-011-0801-5

A series of novel ethyl 7,9-diaryl-1,4-diazaspiro[4.5]dec-9-ene-6- carboxylates was synthesized by the reaction of ethyl 4,6-diaryl-2-oxocyclohex- 3-ene-1-carboxylates with ethylenediamine in the presence of p-toluenesulfonic acid without a solvent under focused microwave irradiation. The title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microorganisms.