On the Synthesis of Tiliacora Alkaloids, I: Synthesis of The Ansymmetrical Dibenzo-1,4-dioxin-Derivative

Article abstract of DOI:10.1002/ardp.19893220805

The N-protected phenylethylamines 2 and 3, respectively, were synthesized in six steps, starting from 2a and 3a.The mixed double Ullmann reaction of 2 with 3 leads to the asymmetrical dibenzo-1,4-dioxin derivative K.On account of the selectively removable protective groups for the amino functions, K is a proper intermediate for the constitution-selective synthesis of the tiliacora alkaloids 1a - 1d.