Biaryl modification of the 5′-terminus of one strand of a microRNA duplex induces strand specificity

DOI: 10.1016/j.bmcl.2010.10.077

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 7299 - 7302 (2010)

Update date:2022-08-05

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Authors:

Ogata, Aya

Furukawa, Chihiro

Sakurai, Kouhei

Iba, Hideo

Kitade, Yukio

Ueno, Yoshihito

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Article abstract of DOI:10.1016/j.bmcl.2010.10.077

MicroRNAs (miRNAs) are single-stranded non-coding RNAs composed of 20-23 nucleotides. They are initially transcribed in the nucleus as pri-miRNAs. After processing, one strand from the miRNA duplex (miR-5p/miR-3p duplex) is loaded onto the RNA-induced sil

Full text of DOI:10.1016/j.bmcl.2010.10.077

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