Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction

DOI: 10.1016/j.tetlet.2010.10.092

Source and publish data:

Tetrahedron Letters p. 6852 - 6855 (2010)

Update date:2022-08-04

Topics:

Authors:

LeClair, Christopher A.

Boxer, Matthew B.

Thomas, Craig J.

Maloney, David J.

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Article abstract of DOI:10.1016/j.tetlet.2010.10.092

A total synthesis of LL-Z1640-2 (2), a potent and selective kinase inhibitor, has been completed. The key step of the convergent synthesis utilized a late-stage intramolecular Nozaki-Hiyama-Kishi (NHK) reaction to close the macrocycle at the C6'-C7' bond.

Full text of DOI:10.1016/j.tetlet.2010.10.092

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