The effect of conformational equilibrium on rate of reactions involving neighbouring group participation

Article abstract of DOI:10.1016/S0040-4020(01)92238-0

The hydrolysis reaction of condensed bromoalkylphthalazinones type 4 is efficiently assisted by the neighbouring hydrazinocarbonyl group. The expected order of anchimeric assistance has been found to be dependent on the chain length. The relatively large