Tetrahedron Letters p. 2625 - 2628 (1991)
Update date:2022-09-26
Topics:
Hashimoto
Shirahama
A general synthetic method of acromelic acid congeners was developed. Various C4-substituents of this family was introduced by the substitution reaction of the corresponding tosylate with diaryl copper lithium. Phenyl derivative 11 showed comparable excitatory activity with kainic acid, and o-anisyl derivative 12 had most potent activity in this family.
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Doi:10.2298/JSC091127003K
(2011)Doi:10.1039/c7ob02828h
(2018)Doi:10.1021/jo00301a025
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(2011)Doi:10.1016/S0040-4039(01)93851-1
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(1983)
