Tetrahedron Letters p. 2625 - 2628 (1991)
Update date:2022-09-26
Topics:
Hashimoto
Shirahama
A general synthetic method of acromelic acid congeners was developed. Various C4-substituents of this family was introduced by the substitution reaction of the corresponding tosylate with diaryl copper lithium. Phenyl derivative 11 showed comparable excitatory activity with kainic acid, and o-anisyl derivative 12 had most potent activity in this family.
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