CONVERSIONS OF 2-α-CHLOROALKYLBENZIMIDAZOLES

Article abstract of DOI:10.1007/BF00534471

Upon interaction with caustic in a DMSO medium, 2-chloromethylbenzimidazoles are subjected to cyclodimerization, forming 5H,12H-pyrazino<1,2-a:4,5-a'>bis-benzimidazoles; in the presence of nucleophiles (ammonia, amines, anions of β-diketones), under the indicated conditions, the products are the corresponding substituted amines or derivatives of pyrrolo<1,2-a>benzimidazole.