Monophosphoric Acid Diesters of 7β-Hydroxycholesterol and of Pyrimidine Nucleosides as Potential Antitumor Agents: Synthesis and Preliminary Evaluation of Antitumor Activity

DOI: 10.1021/jm00170a034

Source and publish data:

Journal of Medicinal Chemistry p. 2264 - 2270 (1990)

Update date:2022-08-02

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Authors:

Ji, Yu-hua

Moog, Christiane

Schmitt, Gaby

Bischoff, Pierre

Luu, Bang

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Article abstract of DOI:10.1021/jm00170a034

7β-Hydroxycholesterol, which has been shown to be selectively cytotoxic toward tumor cells cultered in vitro, was converted into the corresponding water-soluble phosphoric acid ester and linked to a pyrimidine nucleoside such as 5-fluoro-2'-deoxyuridine o

Full text of DOI:10.1021/jm00170a034

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