Monophosphoric Acid Diesters of 7β-Hydroxycholesterol and of Pyrimidine Nucleosides as Potential Antitumor Agents: Synthesis and Preliminary Evaluation of Antitumor Activity

DOI: 10.1021/jm00170a034

Source and publish data:

Journal of Medicinal Chemistry p. 2264 - 2270 (1990)

Update date:2022-08-02

Topics:

Authors:

Ji, Yu-hua

Moog, Christiane

Schmitt, Gaby

Bischoff, Pierre

Luu, Bang

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00170a034

7β-Hydroxycholesterol, which has been shown to be selectively cytotoxic toward tumor cells cultered in vitro, was converted into the corresponding water-soluble phosphoric acid ester and linked to a pyrimidine nucleoside such as 5-fluoro-2'-deoxyuridine o

Full text of DOI:10.1021/jm00170a034

Products guided by the article

Product name:C₄₂H₅₉ClFN₂O₉P

Cas No:128657-22-7

R&D Labs maybe for 128657-22-7

Qingdao Pana-Life Biochem Co.,Ltd.

Contact:86-532-87683902

Address:No.967 Dalao Road, Licang Zone, Qingdao City,Shandong, China 266021
Wuhan Shengmao Corp

website:http://www.shengmaochem.com

Contact:86-27-82853423, 82819281

Address:Rm 202, A Unit Huaqiao Building No. 2, Lihuangpi Road, Wuhan, China
Shenyang NovPharm Technology Co., Ltd.

Contact:.+86-24-24165786

Address:Room 306, Hongjin Mansion, No. 36-1, Wanliutang Rd., Shenhe District, Shenyang, Liaoning, P.R.C.
SHANXI XINTIANYUAN PHARMACEUTICAL CO., LTD.

website:http://www.tychemical.com

Contact:0086-358-3521713 3521715

Address:No. 1 Yintong Road, Shanxi Jiaocheng Economic Development Zone, Xiajiaying Town, Jiaocheng County, Lvliang City, Shanxi Province, China
MENGNA

Contact:18698110882

Address:1303 No2 building,LuoMa Garden,YongAn Road,Hexi District,Tianjin city

Relevant to this article

Magnetically separable CuFe₂O₄/reduced graphene oxide nanocomposites: As a highly active catalyst for solvent free oxidative coupling of amines to imines

Doi:10.1039/c6ra08868f
(2016)
Energy transfer at the single-molecule level: Synthesis of a donor-acceptor dyad from perylene and terrylene diimides

Doi:10.1002/chem.201300439
(2013)
A site-selective and stereospecific cascade Suzuki-Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2′-dihalo 1,1′-biaryls

Doi:10.1039/d1cc00648g
(2021)
Nucleophilic Substitution with Inversion of Configuration at the Nucleophile

Doi:10.1021/jo00207a012
(1985)
An Unusual Thermal Rearrangement of 5,5,6,6-Tetracyano-2-thiabicyclo<2.2.0>hexane to a Thiophene

Doi:10.1021/jo00206a014
(1985)
Total synthesis of the antibiotic erypoegin H and cognates by a PtCl ₂-catalyzed cycloisomerization reaction

Doi:10.1002/anie.200700895
(2007)

Article Doi