EFFICIENT SYNTHESIS OF (+)-NOJIRIMYCIN AND (+)-1-DEOXYNOJIRIMYCIN

Article abstract of DOI:10.1016/0040-4039(90)80078-Z

(+)-Nojirimycin (1a) and (+)-1-deoxynojirimycin (2) have been prepared from 1,2-O-isopropylidene-α-D-glucofuranurono-6,3-lactone (3) by a route involving stereoselective reductive amination of 5-hydroxy-1,2-O-isopropylidene-α-D-xylo-hexofuranurono-6,3-lactone (5a).