Synthesis of novel metabolically stable analogues of D-myo-inositol 1,4,5-trisphosphate

DOI: 10.1016/0040-4039(96)00169-4

Source and publish data:

Tetrahedron Letters p. 1917 - 1920 (1996)

Update date:2022-08-05

Topics:

Authors:

Fauq, Abdul H.

Zaidi, Javid H.

Wilcox, Robert A.

Varvel, Girlie

Nahorski, Stefan R.

Kozikowski, Alan P.

Erneux, Christophe

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Article abstract of DOI:10.1016/0040-4039(96)00169-4

Starting from L-quebrachitol, syntheses and biological activities of three novel analogues of the cellular second messenger D-myo-inositol 1,4,5-trisphosphate (IP₃), 3-deoxy-3-fluoro-D-myo-inositol 1,4-bisphosphate 5-phosphorothioate (1a), 3-deoxy-3-fluoro-D-myo-inositol 1,5-bisphosphate 4-phosphorothioate (1b), and 3-deoxy-3-fluoro-D-myo-inositol 1-phosphate 4,5-bisphosphorothioate (1c) are described.

Full text of DOI:10.1016/0040-4039(96)00169-4

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