Addition of Allylic Metals to α-Aminoaldehydes. Application to the Synthesis of Statine, Ketomethylene and Hydroxyethylene Dipeptide Isosteres

DOI: 10.1016/S0040-4039(00)98790-2

Source and publish data:

Tetrahedron Letters p. 1803 - 1806 (1990)

Update date:2022-07-29

Topics:

Authors:

Prasad, J. V. N. Vara

Rich, Daniel H.

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Article abstract of DOI:10.1016/S0040-4039(00)98790-2

A general and stereoselective method to statine, ketomethylene and hydroxyethylene dipeptide isosteres is described.The key reaction is the diastereoselective allyl metal addition to α-aminoaldehydes.

Full text of DOI:10.1016/S0040-4039(00)98790-2

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