Synthesis and biological evaluation of 1,7,8,8a-tetrahydro-3H-oxazolo[3,4- a]pyrazin-6(5H)-ones as antitumoral agents

DOI: 10.1016/j.bmc.2013.07.019

Source and publish data:

Bioorganic and Medicinal Chemistry p. 5748 - 5753 (2013)

Update date:2022-08-05

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Authors:

Chiacchio, Ugo

Barbera, Vincenzina

Bonfanti, Roberta

Broggini, Gian Luigi

Campisi, Agata

Gazzola, Silvia

Parenti, Rosalba

Romeo, Giovanni

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Article abstract of DOI:10.1016/j.bmc.2013.07.019

A series of 1,7,8,8a-tetrahydro-3H-oxazolo[3,4-a]pyrazin-6(5H)-ones has been synthesized by an intramolecular, palladium(II) catalyzed, aminooxygenation of alkenyl ureas, readily available from glycine allylamides as starting materials. Biological tests s

Full text of DOI:10.1016/j.bmc.2013.07.019

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