Total synthesis of halichondrins: Enantioselective construction of a homochiral pentacyclic C1-C15 intermediate from D-ribose

DOI: 10.1016/S0040-4039(00)97476-8

Source and publish data:

Tetrahedron Letters p. 3813 - 3816 (1990)

Update date:2022-08-03

Topics:

Authors:

Cooper, Arthur J.

Salomon, Robert G.

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Article abstract of DOI:10.1016/S0040-4039(00)97476-8

The remarkable heterobicyclization of a homochiral acyclic precursor, derived diastereoselectively from D-ribose, is exploited in a synthesis of the intricate multicyclic poly ether C1 to C15 segment of halichondrins.

Full text of DOI:10.1016/S0040-4039(00)97476-8

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