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66981-73-5

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Heptanoic acid,7-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]- 66981-73-5
Cas No: 66981-73-5
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier
Tianeptine Manufacturer/High quality/Best price/In stock
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No Data 1 Metric Ton 1 Metric Ton/Day Zibo Dorne chemical technology co. LTD Contact Supplier
Factory Supply Tianeptine
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No Data 1 Gram 360 Metric Ton/Day Ality Chemical Corporation Contact Supplier
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Cas No: 66981-73-5
USD $ 3.0-5.0 / Gram 1 Gram 200 tons Metric Ton/Week Hebei Nengqian Chemical Import and Export Co., LTD Contact Supplier
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Cas No: 66981-73-5
USD $ 50.0-50.0 / Kilogram 25 Kilogram 5000 Kilogram/Week Wuhan Alpha & Omega Pharmaceuticals Co., Ltd Contact Supplier
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No Data 1 Kilogram 3 Metric Ton/Week Qingdao Beluga Import and Export Co., LTD Contact Supplier
Tianeptine acid high purity 98%
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USD $ 10.0-10.0 / Gram 1 Gram 10 Kilogram/Day Hubei Vanz Pharm Co.,Ltd Contact Supplier
BLOOM TECH Advanced API/Technology support Tianeptine CAS 66981-73-5
Cas No: 66981-73-5
USD $ 5.0-5.0 / Kilogram 1 Kilogram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
High quality Tianeptine 99% with best price CAS NO.66981-73-5
Cas No: 66981-73-5
USD $ 1900.0-2000.0 / Kilogram 1 Kilogram 1000 Kilogram/Week Hebei Bosang International Trade Co.,Ltd. Contact Supplier
Manufacturer high quality tianeptine acid CAS NO.66981-73-5
Cas No: 66981-73-5
No Data 100 Gram 100 Metric Ton/Month Shanghai CRM New Material Technology Co., LTD Contact Supplier

66981-73-5 Usage

Uses

Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant

Chemical Properties

White Solid

Originator

Stablon,Servier,France,1983

Therapeutic Function

Antidepressant

Manufacturing Process

A solution of 27.6 g (0.16 mol) of freshly distilled ethyl 7-aminoheptanoate in 40 ml of nitromethane was added all at once and with mechanical stirring to a suspension of 26.2 g (0.08 mol) of 5,8-dichloro-10-dioxo-11- methyldibenzo[c,f]thiazepine(1,2) in 120 ml of nitromethane. The whole was heated to 55°C for 30 minutes, the solvent was then evaporated in vacuo and the residue was taken up in water. The crude ester was extracted with ether. After evaporation of the ether 36 g of crude ester were obtained, and 30 g (0.065 mol) there of were treated under reflux with a solution of 2.8 g (0.07 mol) of sodium hydroxide in 35 ml of ethanol and 25 ml of water. After one hour's refluxing, the alcohol was evaporated in vacuo. The residue was taken up in 150 ml of water. The mixture was twice extracted with 75 ml of chloroform and the aqueous phase was evaporated in vacuo. The sodium salt was then dissolved in 150 ml of chloroform, the solution was dried over sodium sulfate and the product precipitated with anhydrous ether. The salt was filtered off, washed with ether and dried at 50°C. 13 g of sodium 7-[8-chloro-10-dioxo-11-methyldibenzo[c,f]thiazepin-(1,2)-aminoheptanoate,melting with decomposition at about 180°C, were obtained.
InChI:InChI=1/C21H25ClN2O4S/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26)

66981-73-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Tianeptine

1.2 Other means of identification

Product number -
Other names Tianeptina

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:66981-73-5 SDS

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