Irreversible inactivation of papain and cathepsin B by epoxidic substrate analogues

DOI: 10.1016/0223-5234(90)90142-P

Source and publish data:

European Journal of Medicinal Chemistry p. 479 - 487 (1990)

Update date:2022-08-05

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Authors:

Giordano, C.

Gallina, C.

Consalvi, V.

Scandurra, R.

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Article abstract of DOI:10.1016/0223-5234(90)90142-P

Epoxidic substrate analogues related to allylamine (4a-4e) and allyl alcohol (5a-5f) were synthesized and tested as models of cysteine-protease inhibitors.They proved to be irreversible inhibitors of papain and cathepsin B with pseudo-first-order inactiva

Full text of DOI:10.1016/0223-5234(90)90142-P

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