A new class of HIV-1-specific 6-substituted acyclouridine derivatives: Synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

DOI: 10.1021/jm00105a055

Source and publish data:

Journal of Medicinal Chemistry p. 349 - 357 (1991)

Update date:2022-09-26

Topics:

Authors:

Tanaka Tanaka

Baba Baba

Hayakawa

Sakamaki

Miyasaka

Ubasawa Ubasawa

Takashima

Sekiya Sekiya

Nitta Nitta

Shigeta Shigeta

Walker Walker

Balzarini

De Clercq

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Article abstract of DOI:10.1021/jm00105a055

A series of novel acyclouridine derivatives substituted at both the C-5 and C-6 positions were synthesized for the purpose of improving the activity of a recently reported HIV-1-specific lead, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). Prep

Full text of DOI:10.1021/jm00105a055

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Product name:5-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)uracil

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