A new class of HIV-1-specific 6-substituted acyclouridine derivatives: Synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

DOI: 10.1021/jm00105a055

Source and publish data:

Journal of Medicinal Chemistry p. 349 - 357 (1991)

Update date:2022-09-26

Topics:

Authors:

Tanaka Tanaka

Baba Baba

Hayakawa

Sakamaki

Miyasaka

Ubasawa Ubasawa

Takashima

Sekiya Sekiya

Nitta Nitta

Shigeta Shigeta

Walker Walker

Balzarini

De Clercq

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00105a055

A series of novel acyclouridine derivatives substituted at both the C-5 and C-6 positions were synthesized for the purpose of improving the activity of a recently reported HIV-1-specific lead, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). Prep

Full text of DOI:10.1021/jm00105a055

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Product name:5-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)uracil

Cas No:131194-23-5

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