A new class of HIV-1-specific 6-substituted acyclouridine derivatives: Synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

DOI: 10.1021/jm00105a055

Source and publish data:

Journal of Medicinal Chemistry p. 349 - 357 (1991)

Update date:2022-09-26

Topics:

Authors:

Tanaka Tanaka

Baba Baba

Hayakawa

Sakamaki

Miyasaka

Ubasawa Ubasawa

Takashima

Sekiya Sekiya

Nitta Nitta

Shigeta Shigeta

Walker Walker

Balzarini

De Clercq

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00105a055

A series of novel acyclouridine derivatives substituted at both the C-5 and C-6 positions were synthesized for the purpose of improving the activity of a recently reported HIV-1-specific lead, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). Prep

Full text of DOI:10.1021/jm00105a055

Products guided by the article

Product name:5-benzoyl-1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)uracil

Cas No:131194-23-5

R&D Labs maybe for 131194-23-5

Luna Chemicals Co.,Ltd.

Contact:+86-570-4336358

Address:No.87 Building,Tianqian,Sidu Town
QUZHOU ZIO I/E CO.;LTD

Contact:13357117572

Address:No.149 Shiji dadao Road.
Qingdao Pana-Life Biochem Co.,Ltd.

Contact:86-532-87683902

Address:No.967 Dalao Road, Licang Zone, Qingdao City,Shandong, China 266021
SuZhou Yacoo Science Co., Ltd

Contact:86-512-87182055

Address:No.128 Fangzhou Rd, Suzhou Industrial Park, China, 215125, China
Xian Changyue Biological Technology Co., Ltd.

website:https://www.xachangyue.com/

Contact:+86-029-88211911

Address:Keji Road NO.70

Relevant to this article

Asymmetric synthesis of β²-tryptophan analogues via Friedel-Crafts alkylation of indoles with a chiral nitroacrylate

Doi:10.1021/jo200733t
(2011)
Improved synthesis of substituted pyrido[2,3-d]pyrimidinediones

Doi:10.1016/j.tetlet.2011.05.021
(2011)
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2

Doi:10.1016/j.bmcl.2012.10.008
(2012)
Synthesis of novel haptens and conjugates for antibody production against kainoid family

Doi:10.1055/s-0030-1258479
(2010)
Tricyclic analogues of artemisinin: Synthesis and antimalarial activity of (+)-4,5-secoartemisinin and (-)-5-Nor-4,5-secoartemisinin

Doi:10.1039/c39900001487
(1990)
Synthesis and crystal structure of a new Cd(II) coordination polymer based on a 1,10-phenanthroline derivative

Doi:10.1515/znb-2011-0515
(2011)

Article Doi