Synthesis of C-(beta-D-glycosyl) analogues of 3-deoxy-D-manno-2-octulosonic acid (Kdo) as potential inhibitors of CMP-Kdo synthetase.

DOI: 10.1016/0008-6215(90)80066-C

Source and publish data:

Carbohydrate research p. 269 - 276 (1990)

Update date:2022-07-29

Topics:

Authors:

Waglund Waglund

Luthman Luthman

Orbe Orbe

Claesson

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Article abstract of DOI:10.1016/0008-6215(90)80066-C

Eight C-(beta-D-glycosyl) analogues (14-21) of Kdo (3-deoxy-D-manno-2-octulosonic acid) were obtained from isopropylidene-protected ester precursors and tested in vitro for their inhibitory activity on CMP-Kdo synthetase. None had more than minor inhibitory activity.

Full text of DOI:10.1016/0008-6215(90)80066-C

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