Synthesis of High Specific Activity (+)- and (-)-6-Fluoronorepinephrine via the Nucleophilic Aromatic Substitution Reaction

DOI: 10.1021/jm00106a043

Source and publish data:

Journal of Medicinal Chemistry p. 767 - 771 (1991)

Update date:2022-08-05

Topics:

Authors:

Ding, Yu-Shin

Fowler, Joanna S.

Gatley, S. John

Dewey, Stephen L.

Wolf, Alfred P.

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Article abstract of DOI:10.1021/jm00106a043

The first example of a no-carrier-added 18F-labeled catecholamine, 6-<18F>fluoronorepinephrine (6-<18F>FNE), has been synthesized via nucleophilic aromatic substitution.The racemic mixture was resolved on a chiral HPLC column to obtain pure samples of (-)

Full text of DOI:10.1021/jm00106a043

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