Synthesis of High Specific Activity (+)- and (-)-6-Fluoronorepinephrine via the Nucleophilic Aromatic Substitution Reaction

Article abstract of DOI:10.1021/jm00106a043

The first example of a no-carrier-added 18F-labeled catecholamine, 6-<18F>fluoronorepinephrine (6-<18F>FNE), has been synthesized via nucleophilic aromatic substitution.The racemic mixture was resolved on a chiral HPLC column to obtain pure samples of (-)