Organic Process Research and Development p. 507 - 511 (2012)
Update date:2022-08-04
Topics:
Pramanik, Chinmoy
Bhumkar, Rahul
Karhade, Ganesh
Khairnar, Pravinkumar
Tripathy, Narendra Kumar
Gurjar, Mukund K.
During the commercial manufacturing of antimigraine drug Rizatriptan benzoate, several impurities are reported to be formed. This present work demonstrates a convergent and short synthesis of the most critical impurity (C) of Rizatriptan, [2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indole-2-yl)-N,N- dimethylethanamine (1)], recently reported in U.S. Pharmacopeia.
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Doi:10.1016/j.bmc.2011.06.045
(2011)Doi:10.1002/jhet.648
(2011)Doi:10.1021/jm301654b
(2013)Doi:10.1007/BF00807429
(1995)Doi:10.1016/S0040-4020(01)89051-7
(1990)Doi:10.1039/c0ob00308e
(2010)
