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  • Factory price Additives 25kg bag Thickener xanthan gum powder 80 mesh 200 mesh 11138-66-2 cosmetic grade

    Cas No: 11138-66-2

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11138-66-2 Usage


Xanthan gum is a long chain polysaccharide produced by microbial fermentation from the Xanthomonas campestris organism. It is a highly stable and versatile biopolymer with unique rheological properties, making it an essential ingredient in various industries.


Used in Food Industry:
Xanthan gum is used as a stabilizer and thickening agent for various food products, such as salad dressings, sauces, desserts, baked goods, and beverages. It helps control the rheological properties of these products, providing a consistent texture and improving their overall quality. It is also used in combination with other gums like guar gum, tara gum, and carob gum to enhance viscosity and gel formation.
Used in Pharmaceutical Industry:
Xanthan gum serves as a thickening and stabilizing agent in toothpastes and medicines. It is also used in the development of medications for lowering blood sugar and total cholesterol levels in individuals with diabetes. Additionally, it is utilized as a laxative and sometimes as a saliva substitute for people with dry mouth conditions, such as Sjogren's syndrome.
Used in Cosmetics Industry:
Xanthan gum is employed as a texturizer, carrier agent, and gelling agent in cosmetic preparations. It helps stabilize and thicken formulations, providing a smooth and consistent texture.
Used in Water-based Systems:
Xanthan gum is used for rheology control in water-based systems, ensuring the proper flow and consistency of various products.
Used in Oil and Gas Industry:
In the oil and gas sector, xanthan gum is utilized in drilling and completion fluids to improve their performance and efficiency.
Chemical Properties:
Xanthan gum has a viscosity of 1% solution ranging from 1,200-1,600 mPas and occurs as a creamor white-colored, odorless, free-flowing fine powder.
Brand Name:
One of the brand names for xanthan gum is Rhodigel, produced by Vanderbilt.

Occurrence, Isolation

Xanthan gum, the extracellular polysaccharide from Xanthomonas campestris and some related microorganisms, is produced on a nutritive medium containing glucose, NH4Cl, a mixture of amino acids, and minerals. The polysaccharide is recovered from the medium by isopropanol precipitation in the presence of KCl.

analysis of bacterial polysaccharide

Xanthan gum is a high-molecular-weight polysaccharide gum produced by a pureculture fermentation of a carbohydrate with the gram-negative bacteria Xanthomonas campestris. This natural polysaccharide is widely used in the food industry and to a lesser extent in the pharmaceutical industry. Xanthan gum is monographed in the USP28/NF and in the PhEur. It is soluble in hot and cold water, as well as being stable under acidic and alkaline conditions (pH 5–13).The primary structure of xanthan gum contains D-glucose and D-mannose as the dominant hexose units, along with D-glucuronic acid. The trisaccharide side chain consists of two D-mannose residues and one D-glucuronic acid residue occurring as mixed K+, Na+, and Ca++ salts. Through the association of xanthan molecules, it is thought that a quaternary structure arises through the charged trisaccharide side chains. Xanthan gum is a water-soluble polymer. Neither USP nor PhEur provides an HPLC method for determination of identity or purity.


[1] http://www.webmd.com [2] https://en.wikipedia.org/wiki/Xanthan_gum

Production Methods

Xanthan gum is a polysaccharide produced by a pure-culture aerobic fermentation of a carbohydrate with Xanthomonas campestris. The polysaccharide is then purified by recovery with propan-2-ol, dried, and milled.

Pharmaceutical Applications

Xanthan gum is widely used in oral and topical pharmaceutical formulations, cosmetics, and foods as a suspending and stabilizing agent. It is also used as a thickening and emulsifying agent. It is nontoxic, compatible with most other pharmaceutical ingredients, and has good stability and viscosity properties over a wide pH and temperature range. Xanthan gum gels show pseudoplastic behavior, the shear thinning being directly proportional to the shear rate. The viscosity returns to normal immediately on release of shear stress. Xanthan gum has been used as a suspending agent for conventional, dry and sustained-release suspensions. When xanthan gum is mixed with certain inorganic suspending agents, such as magnesium aluminum silicate, or organic gums, synergistic rheological effects occur. In general, mixtures of xanthan gum and magnesium aluminum silicate in ratios between 1 : 2 and 1 : 9 produce the optimum properties. Similarly, optimum synergistic effects are obtained with xanthan gum : guar gum ratios between 3 : 7 and 1 : 9. Although primarily used as a suspending agent, xanthan gum has also been used to prepare sustained-release matrix tablets. Controlled-release tablets of diltiazem hydrochloride prepared using xanthan gum have been reported to sustain the drug release in a predictable manner, and the drug release profiles of these tablets were not affected by pH and agitation rate. Xanthan gum has also been used to produce directly compressed matrices that display a high degree of swelling due to water uptake, and a small amount of erosion due to polymer relaxation. It has also been used in combination with chitosan, guar gum, galactomannan, and sodium alginate to prepare sustained-release matrix tablets. Xanthan gum has been used as a binder, and in combination with Konjac glucomannan is used as an excipient for controlled colonic drug delivery. Xanthan gum with boswellia (3 : 1) and guar gum (10 : 20) have shown the best release profiles for the colon-specific compression coated systems of 5- fluorouracil for the treatment of colorectal cancer. Xanthan gum has also been used with guar gum for the development of a floating drug delivery system.It has also has derivatized to sodium carboxymethyl xanthan gum and crosslinked with aluminum ions to prepare microparticles, as a carrier for protein delivery. Xanthan gum has been incorporated in an ophthalmic liquid dosage form, which interacts with mucin, thereby helping in the prolonged retention of the dosage form in the precorneal area. When added to liquid ophthalmics, xanthan gum delays the release of active substances, increasing the therapeutic activity of the pharmaceutical formulations. Xanthan gum can be used to increase the bioadhesive strength in vaginal formulations. Xanthan gum alone or with carbopol 974P has been used as a mucoadhesive controlled-release excipient for buccal drug delivery. Modified xanthan films have been used as a matrix system for transdermal delivery of atenolol. Xanthan gum has also been used as a gelling agent for topical formulations incorporating solid lipid nanoparticles of vitamin A or microemulsion of ibuprofen. A combined polymer system consisting of xanthan gum, carboxy methylcellulose and a polyvinyl pyrolidone backboned polymer has been used for relieving the symptoms of xerostomia. Xanthan gum can also be used as an excipient for spray-drying and freeze-drying processes for better results. It has been successfully used alone or in combination with agar for microbial culture media. Xanthan gum is also used as a hydrocolloid in the food industry, and in cosmetics it has been used as a thickening agent in shampoo. Polyphosphate with xanthum gum in soft drinks is suggested to be effective at reducing erosion of enamel

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.


Xanthan gum is widely used in oral and topical pharmaceutical formulations, cosmetics, and food products, and is generally regarded as nontoxic and nonirritant at the levels employed as a pharmaceutical excipient. The estimated acceptable daily intake for xanthan gum has been set by the WHO at up to 10 mg/kg body-weight. No eye or skin irritation has been observed in rabbits and no skin allergy has been observed in guinea pigs following skin exposure. No adverse effects were observed in long term feeding studies with rats (up to 1000 mg/kg/day) and dogs (up to 1000 mg/kg/day). No adverse effects were observed in a three-generation reproduction study with rats (up to 500 mg/kg/day). LD50 (dog, oral): >20 g/kg LD50 (rat, oral): >45 g/kg LD50 (mouse, oral): >1 g/kg LD50 (mouse, IP): >50 mg/kg LD50 (mouse, IV): 100–250 mg/kg


Xanthan gum is a stable material. Aqueous solutions are stable over a wide pH range (pH 3–12), although they demonstrate maximum stability at pH 4–10 and temperatures of 10–60°C. Xanthan gum solutions of less than 1% w/v concentration may be adversely affected by higher than ambient temperatures: for example, viscosity is reduced. Xanthan gum provides the same thickening, stabilizing, and suspending properties during long-term storage at elevated temperatures as it does at ambient conditions. In addition, it ensures excellent freeze–thaw stability. Solutions are also stable in the presence of enzymes, salts, acids, and bases. Vanzan NF-ST is especially designed for use in systems containing high salt concentrations as it dissolves directly in salt solutions, and its viscosity is relatively unaffected by high salt levels as compared with general purpose grades. The bulk material should be stored in a well-closed container in a cool, dry place.


Xanthan gum is an anionic material and is not usually compatible with cationic surfactants, polymers, or preservatives, as precipitation occurs. Anionic and amphoteric surfactants at concentrations above 15% w/v cause precipitation of xanthan gum from a solution. Under highly alkaline conditions, polyvalent metal ions such as calcium cause gelation or precipitation; this may be inhibited by the addition of a glucoheptonate sequestrant. The presence of low levels of borates (<300 ppm) can also cause gelation. This may be avoided by increasing the boron ion concentration or by lowering the pH of a formulation to less than pH 5. The addition of ethylene glycol, sorbitol, or mannitol may also prevent this gelation. Xanthan gum is compatible with most synthetic and natural viscosity-increasing agents, many strong mineral acids, and up to 30% inorganic salts. If it is to be combined with cellulose derivatives, then xanthan gum free of cellulase should be used to prevent depolymerization of the cellulose derivative. Xanthan gum solutions are stable in the presence of up to 60% water-miscible organic solvents such as acetone, methanol, ethanol, or propan-2- ol. However, above this concentration precipitation or gelation occurs. The viscosity of xanthan gum solutions is considerably increased, or gelation occurs, in the presence of some materials such as ceratonia, guar gum, and magnesium aluminum silicate. This effect is most pronounced in deionized water and is reduced by the presence of salt. This interaction may be desirable in some instances and can be exploited to reduce the amount of xanthan gum used in a formulation. Xanthan gum is incompatible with oxidizing agents, some tablet film-coatings, carboxymethylcellulose sodium, dried aluminum hydroxide gel, and some active ingredients such as amitriptyline, tamoxifen, and verapamil.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral solutions, suspensions, and tablets; rectal and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Check Digit Verification of cas no

The CAS Registry Mumber 11138-66-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,1,3 and 8 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 11138-66:
72 % 10 = 2
So 11138-66-2 is a valid CAS Registry Number.

11138-66-2 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
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  • TCI America

  • (X0048)  Xanthan Gum  

  • 11138-66-2

  • 25g

  • 405.00CNY

  • Detail
  • TCI America

  • (X0048)  Xanthan Gum  

  • 11138-66-2

  • 100g

  • 780.00CNY

  • Detail
  • TCI America

  • (X0048)  Xanthan Gum  

  • 11138-66-2

  • 500g

  • 1,930.00CNY

  • Detail
  • Sigma

  • (43708)  Xanthan from Xanthomonas campestris  

  • 11138-66-2

  • 43708-50G

  • 369.60CNY

  • Detail
  • Sigma

  • (43708)  Xanthan from Xanthomonas campestris  

  • 11138-66-2

  • 43708-1KG

  • 3,658.01CNY

  • Detail
  • Sigma

  • (43708)  Xanthan from Xanthomonas campestris  

  • 11138-66-2

  • 43708-250G

  • 1,463.20CNY

  • Detail
  • Sigma

  • (G1253)  XanthangumfromXanthomonascampestris  

  • 11138-66-2

  • G1253-100G

  • 699.66CNY

  • Detail
  • Sigma

  • (G1253)  XanthangumfromXanthomonascampestris  

  • 11138-66-2

  • G1253-500G

  • 2,575.17CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name Xanthan Gum

1.2 Other means of identification

Product number -
Other names 1,1,2,2-Tridecafluoro-1-iodo--octane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:11138-66-2 SDS

11138-66-2Downstream Products

11138-66-2Related news

Acetylation of Xanthan gum (cas 11138-66-2) in densified carbon dioxide (CO2)07/21/2019

Xanthan Gum (XG), known as a microbial polysaccharide, is potential renewable resources in the biodegradable plastics synthesis. However, native xanthan gum needs to be chemically modified in order to improve its properties required for further application as thermoplastics material. We here rep...detailed

11138-66-2Relevant articles and documents

Isolation, biochemical characterization and production of biopolymers by phytopathogenic species of xanthomonas from the plants of rutaceae family


experimental part, p. 285 - 287 (2011/11/28)

Plants of rutaceae family, such as Citrus medica (citron, bijaura), Limonia acidissima (stone fruit, elephant apple) and Citrus limon (lemon) are well known for their nutritive and medicinal values. They were analyzed for the presence of citrus cankers on their various body parts such as leaves, stems and fruits. Isolated species of Xanthomonas were subjected to biochemical characterization for their identification. Different media were used for the cultivation of these organisms as well as production of biolpolymer from them under laboratory conditions. Isolated species were subjected to cross infect these three members of rutaceae family to investigate their host range. Different sugars, such as glucose and sucrose were tested for optimization of xanthan production. Biopolymers from Xanthomonas spp. have got wide spread biotechnological applications.

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