A formal synthesis of (-)-cyanolide a featuring a stereoselective mukaiyama aldol reaction and oxocarbenium reduction

Article abstract of DOI:10.1021/jo201210u

The formal synthesis of the marine natural product (-)-cyanolide A is presented. The synthetic strategy is centered on two acyclic diastereoselective reactions and a single cyclic reaction with modest to excellent dr based on an initial stereocenter. Most