NAD(P)H-NAD(P)+ Models. 73. Structure-Stereochemistry Relationship in the Reaction of NAD Analog

Article abstract of DOI:10.1246/bcsj.64.81

Four different NAD(P)H analogs have been oxidized by various substituted and unsubstituted 1,4-benzoquinones in the presence or absence of magnesium ion.The stereospecificity of the reaction depends not only on the reactivity of quinone but also on that of the analogs as well as on the presence or absence of magnesium ion.The results are discussed from the viewpoint of reaction mechanism for the transfer of a (net) hydride ion.