
Helvetica Chimica Acta p. 896 - 901 (1990)
Update date:2022-08-04
Topics:
Rautenstrauch, Valentin
Snowden, Roger L.
Linder, Simon M.
(+/-)-Muscone ((+/-)-1) has been synthesized in three steps from 2-(2'-methylprop-2'-enyl)cyclododecan-1-one (2).The synthesis involves two key transformations: a Lewis-acid-mediated intramolecular ene reaction (2 -> 3) and the β-cleavage of the bicyclic potassium alkoxide 3a' to the macrocyclic enone (Z)-11.
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