92. A Short Synthesis of (+/-)-Muscone

Article abstract of DOI:10.1002/hlca.19900730416

(+/-)-Muscone ((+/-)-1) has been synthesized in three steps from 2-(2'-methylprop-2'-enyl)cyclododecan-1-one (2).The synthesis involves two key transformations: a Lewis-acid-mediated intramolecular ene reaction (2 -> 3) and the β-cleavage of the bicyclic potassium alkoxide 3a' to the macrocyclic enone (Z)-11.