1,2,3-Triazolo[5,1-b]thiazoles. Part 2 lithiation experiments leading to 2,4-disubstituted thiazoles

Article abstract of DOI:10.1016/S0040-4020(01)87091-5

3-Methyltriazolothiazole (2) and 3-phenyltriazolothiazole (3) were regiospecifically lithiated at position 6, triazolothiazole (1) at position 6 and 3 with the former predominating. The lithiated triazolothiazoles (4), (10) and (11) reacted with a number of electrophiles to give x:6-disubstituted triazolothiazoles, which could be converted into 2,4-disubstituted thiazoles.