The use of p-toluenesulfonic acid for removal of the N-T-butoxy-carbonyl protecting group in solid phase peptide synthesis

Article abstract of DOI:10.1080/00397919108016770

The usefulness of p-toluenesulfonic acid in THF/CH₂Cl₂ for Boc removal in solid phase peptide synthesis has been demonstrated through the syntheses of Leu-5 and Met-5 enkephalin acids.

Full text of DOI:10.1080/00397919108016770

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Synthetic Communications: An
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Organic Chemistry
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The Use of P-Toluenesulfonic
Acid for Removal of the N-T-
Butoxy-Carbonyl Protecting
Group in Solid Phase Peptide
Synthesis
Herbert R. Brinkman a , John J. Landi Jr a , Joseph
B. Paterson Jr. a & Paul J. Stone a
a Contribution from the Chemical Development
Department, Hoffmann-La Roche Inc., 340 Kingsland
Street, Nutley, New Jersey, 07110
Published online: 24 Sep 2006.
To cite this article: Herbert R. Brinkman , John J. Landi Jr , Joseph B. Paterson
Jr. & Paul J. Stone (1991) The Use of P-Toluenesulfonic Acid for Removal of the N-
T-Butoxy-Carbonyl Protecting Group in Solid Phase Peptide Synthesis, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 21:3, 459-465, DOI: 10.1080/00397919108016770
To link to this article: http://dx.doi.org/10.1080/00397919108016770
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