Synthesis of N1,4-Di(p-coumaroyl)spermine, a possible biogenetic precursor of aphelandrine

Article abstract of DOI:10.1002/hlca.19910740322

Coupling of two differently substituted 1,3-diaminopropane units 5 and 6 (Schemes 1 and 2) lead to the key intermediate 8, a tetra-N-protected spermine derivative. By selective deprotection and alkylation with (E)-4-(mesy1oxy) cinnamoyl chloride, followed