A New Vinylsilane Substitution Reaction with Glyoxylate: Asymmetric Synthesis of α-Hydroxy β,γ-Unsaturated Esters

Article abstract of DOI:10.1021/jo00014a002

The vinylsilane substitution reaction with glyoxylate and the asymmetric version thereof are described.These new reactions provide α-hydroxy β,γ-unsaturated esters of biological and synthetic importance in high enantiomeric and geometric purity.