8-ARYL-2-AZABICYCLONONAN-7-ONES. SYNTHESIS AND RETRO-MICHAEL OPENING

DOI: 10.1016/S0040-4020(01)87110-6

Source and publish data:

Tetrahedron p. 4417 - 4428 (1991)

Update date:2022-08-04

Topics:

Authors:

Bonjoch, Josep

Quirante, Josefina

Sole, Daniel

Castells, Josep

Galceran, Montserrat

Bosch, Joan

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Article abstract of DOI:10.1016/S0040-4020(01)87110-6

The synthesis of 8-aryl-2-azabicyclo<3.3.1>nonan-7-ones (7) by acid cyclization of 4-(3-aryl-2-oxopropyl)-2-piperidinecarbonitriles (5) is reported.Bicyclic α-aryl-β-amino ketones 7 easily undergo a retro-Michael ring opening to give the corresponding 2-a

Full text of DOI:10.1016/S0040-4020(01)87110-6

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