8-ARYL-2-AZABICYCLONONAN-7-ONES. SYNTHESIS AND RETRO-MICHAEL OPENING

DOI: 10.1016/S0040-4020(01)87110-6

Source and publish data:

Tetrahedron p. 4417 - 4428 (1991)

Update date:2022-08-04

Topics:

Authors:

Bonjoch, Josep

Quirante, Josefina

Sole, Daniel

Castells, Josep

Galceran, Montserrat

Bosch, Joan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(01)87110-6

The synthesis of 8-aryl-2-azabicyclo<3.3.1>nonan-7-ones (7) by acid cyclization of 4-(3-aryl-2-oxopropyl)-2-piperidinecarbonitriles (5) is reported.Bicyclic α-aryl-β-amino ketones 7 easily undergo a retro-Michael ring opening to give the corresponding 2-a

Full text of DOI:10.1016/S0040-4020(01)87110-6

Products guided by the article

Product name:1-Benzyl-4-<2,2-(ethylenedioxy)-3-(o-nitrophenyl)propyl>piperidine

Cas No:135634-74-1

R&D Labs maybe for 135634-74-1

Ningbo Inno Pharmchem Co., Ltd.

Contact:86-574-87319282

Address:6F-5,NO.163 RUIQING RD.,NINGBO 315000 CHINA
Jiangxi Huashi Pharmaceutical Co., Ltd

Contact:+86-795-4509628

Address:No.199, Ningbo Avenue, Fengxin industrial park, Fengxin county, Yichun city, Jiangxi
Jinan Finer Chemical Co., Ltd

website:https://www.finerchem.com

Contact:+86-531-88989536

Address:New Material Industrial Park, Jinan City, China
Wuxi Zuping Food Science And Technology Co.,LTD.

Contact:+86-510-87210822

Address:Guanlin town
Shanghai Taibao Pharmaceutical Technology Co., Ltd(expird)

Contact:021-52217366

Address:shanghai

Relevant to this article

Synthesis of novel tri-arm star shaped 1,3,5-triazine hydrazones from 2,4,6-tris(4-acetylphenoxy)-1,3,5-triazine Core

Doi:10.2174/157017812799304051
(2012)
Organophosphorus-selenium heteroatom derivatives from selenation of primary/secondary amines and haloalkanes/dihaloalkanes

Doi:10.1002/ejoc.201300860
(2013)
About the intermediacy of 1,2-dihydroquinazolinium salts in the Friedl?nder-Borsche synthesis of quinolinium salts in acidic medium

Doi:10.1016/j.tetlet.2011.09.053
(2011)
Cleavage of the phosphodiester bond of uridylyl-(3′,5′)-8-carboxymethylaminoadenosine by hydronium, hydroxide and zinc(II) ions: A model study aimed at elucidating the potential of a carboxylate function as an intramolecular catalyst

Doi:10.1080/15257770008045452
(2000)
From COX-2 inhibitor nimesulide to potent anti-cancer agent: Synthesis, in vitro, in vivo and pharmacokinetic evaluation

Doi:10.1016/j.ejmech.2011.11.012
(2012)
New thiazole carboxamides as potent inhibitors of Akt kinases

Doi:10.1016/j.bmcl.2011.11.080
(2012)

Article Doi