CAS No.119-36-8,Methyl salicylate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	119-36-8
Name:	Methyl salicylate
Article Data:	265
Cas Database

Formula:	C₈H₈O₃
Molecular Weight:	152.15
Synonyms:	Gaultheria Oil, artificial;Benzoic acid,2-hydroxy-,esters,methyl ester;Teaberry oil;Gaultheriaoel;2-(Methoxycarbonyl)phenol;Wintergruenoel;o-Hydroxybenzoic acid, methyl ester;Natural Wintergreen Oil;Betula;Salicylic acid, methyl ester;Methyl salicylate (JP14/NF);Oil of Wintergreen;Methyl salicylate BP;Methyl Hydroxy benzoate;Methyl salicylic acid;methyl salicylate;2-carbomethoxyphenol; methyl o-hydroxybenzoate;Wintergreen oil;Methyl 2-hydroxybenzoate;Gaultheria oil;Metylester kyseliny salicylove;Methyl o-hydroxybenzoate;Benzoic acid, 2-hydroxy-, methyl ester;Spicewood Oil;Flucarmit;
EINECS:	204-317-7
Density:	1.209 g/cm³
Melting Point:	-8 °C
Boiling Point:	222 °C at 760 mmHg
Flash Point:	86.8 °C
Solubility:	0.07 g/100 mL (20 °C) in water
Appearance:	colourless liquid with an odour of wintergreen
Hazard Symbols:	Xn
Risk Codes:	22-36/38-36/37/38
Safety:	26-36-24/25
PSA:	46.53000
LogP:	1.17880

Synthetic route

: 69-72-7
salicylic acid

: 119-36-8
methyl salicylate

: 67490-09-9
1-carbomethoxybenzene 1,2-oxide

: 119-36-8
methyl salicylate

Conditions

Conditions	Yield
With trifluoroacetic acid In tetrahydrofuran; water pH 0.1; further pH;	100%
With phosphate buffer In tetrahydrofuran; water Product distribution; Mechanism; other pH;	100%

: 18001-14-4
2-trimethylsilanyloxy-benzoic acid methyl ester

: 119-36-8
methyl salicylate

Conditions

Conditions	Yield
montmorillonite K-10 for 0.05h; Solid phase reaction; desilylation; microwave irradiation;	100%
With dichloro bis(acetonitrile) palladium(II) In water; acetone at 75℃; for 14h;	93%

Raw Materials

93-58-3

888-12-0

134-20-3

110-89-4

110-00-9

95-48-7

24396-24-5

75-36-5

Downstream Products

67-56-1

108-95-2

580-02-9

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Specification

1. Introduction of Methyl salicylate
Methyl salicylate is colorless or light pale yellow liquid with Characteristic odor. The IUPAC Name of it is methyl 2-hydroxybenzoate.

2. Properties of Methyl salicylate
Index of Refraction: 1.547
Molar Refractivity: 39.9 cm³
Molar Volume: 125.7 cm³
Polarizability: 15.82×10^-24cm³
Surface Tension: 45.7 dyne/cm
Density: 1.209 g/cm³
Flash Point: 86.8 °C
Enthalpy of Vaporization: 47.71 kJ/mol
Melting Point: -8 °C
Boiling Point: 222 °C at 760 mmHg
Vapour Pressure: 0.07 mmHg at 25°C
Water Solubility: 0.07 g/100 mL (20 ºC)
Stability: Stable. Incompatible with strong oxidizing agents, strong bases.

3. Structure Descriptors of Methyl salicylate
Product Categories: INORGANIC & ORGANIC CHEMICALS;FINE Chemical & INTERMEDIATES;Cosmetic Ingredients & Chemicals
Canonical SMILES: COC(=O)C1=CC=CC=C1O
InChI: InChI=1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3
InChIKey: OSWPMRLSEDHDFF-UHFFFAOYSA-N

4. Toxicity of Methyl salicylate

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	228mg/kg (228mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of Diseases of Children. Vol. 69, Pg. 37, 1945.
child	LDLo	oral	700mg/kg (700mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: GENERAL ANESTHETIC	Archives of Disease in Childhood. Vol. 28, Pg. 475, 1953.
dog	LD50	oral	2100mg/kg (2100mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978.
dog	LDLo	subcutaneous	2250mg/kg (2250mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978.
guinea pig	LD50	oral	700mg/kg (700mg/kg)		"Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63Vol. 2, Pg. 1897, 1963.
guinea pig	LDLo	subcutaneous	1500mg/kg (1500mg/kg)		FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 63, 1967.
human	LDLo	oral	506mg/kg (506mg/kg)		"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 961, 1989.
infant	LDLo	oral	1480mg/kg (1480mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937.
man	LDLo	oral	101mg/kg (101mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937.
man	LDLo	oral	1329mg/kg (1329mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: COMA BLOOD: HEMORRHAGE	Clinical Toxicology. Vol. 6, Pg. 189, 1973.
man	LDLo	unreported	522mg/kg (522mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	oral	1110mg/kg (1110mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 207, 1961.
rabbit	LD50	oral	1300mg/kg (1300mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978.
rabbit	LDLo	subcutaneous	4250mg/kg (4250mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 821, 1978.
rat	LD50	oral	887mg/kg (887mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
women	LDLo	oral	355mg/kg (355mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of the Medical Sciences. Vol. 193, Pg. 772, 1937.

5. Safety Information of Methyl salicylate

Hazard Codes: Harmful Xn
Risk Statements: 22-36/38-36/37/38
R22:Harmful if swallowed.
R36/38:Irritating to eyes and skin.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S24/25:Avoid contact with skin and eyes.
RIDADR: 3082
WGK Germany: 1
RTECS: VO4725000
F: 8
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 119-36-8(Hazardous Substances Data)

6. Preparation of Methyl salicylate
Methyl salicylate can be produced by esterifying salicylic acid with methanol. Commercial methyl salicylate is now synthesized, but in the past, it was commonly distilled from the twigs of Betula lenta (sweet birch) and Gaultheria procumbens.

7. Use of Methyl salicylate
Methyl salicylate is commonly used as spices of food, toothpaste and cosmetics.It is also used to produce antalgesic drugs, pesticides, rubbing agent, ink, etc. Methyl Salicylate is used in flavoring for foods, candies, beverages and pharmaceuticals. It is used as a perfumery like magnolia, meadowsweet, root beer. It is also an odorant, perfume and ultraviolet absorber in cosmetics. This compound is used in medicine mainly for dephlogistication, analgesia. It is used in liniments and ointments for the relief of pain of lumbago, sciatica and rheumatics.

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