
Journal of Organic Chemistry p. 6406 - 6411 (1991)
Update date:2022-08-04
Topics:
Maggini, Michele
Passudetti, Margherita
Gonzales-Trueba, Guadalupe
Prato, Maurizio
Quintily, Ugo
Scorrano, Gianfranco
The synthesis of several fluoroaromatic compounds by a new procedure of fluorodenitration of nitroarenes is reported.The methodology is based on the principle that the nitrite ion, generated during the fluorodenitration processes and responsible for most of the undesired side reactions, can be trapped with a suitable reagent, e.g., phthaloyl difluoride or tetrafluorophthaloyl difluoride.The yields of fluoro compounds thus obtained are good to excellent, and the procedure is of general application.
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