Simple synthesis of 4-thiothymidine, 4-thiouridine and 6-thio-2′-deoxyguanosine

Article abstract of DOI:10.1016/0040-4039(91)85095-M

4-triazolo-pyrimidine nucleosides and 6-O-(mesitylenesulfonyl)-2′-deoxyguanosine, when treated with thiolacetic acid at room temperature, gave the corresponding 4-thiopyrimidine nucleosides and 6-thio-2′-deoxyguanosine with high yields (86-93%). Possible mechanisms are discussed.