Total Synthesis of (+/-)-Clavukerin A: A New Trinorguaiane Sesquiterpene. Biomimetic Synthesis of (+/-)-Clavularin A from (+/-)-Clavukerin A

Article abstract of DOI:10.1021/jo00024a024

(+/-)-Clavukerin A, 2,8-dimethylbicyclo<5.3.0>deca-5,7-diene, was first synthesized utilizing thermal <2+2> cycloaddition and two carbon ring expansion reactions as key elements. (+/-)-Clavukerin A was transformed, via photooxidation mimicking the biogene