Weigh the sample of about 750mg. Put it into a dry conical flask of 200ml. Add glacial acetic acid of 75 ml to it. Heat the mixture on the heating plate and after it dissolves, get it cooled. Add several drops of quinaldine red solution (TS-203), use glacial acetic acid solution of 0.1mol/L perchloric acid to titrate the mixture until it gets colorless through microburet of 10ml. Perchloric acid per ml0.1mol/L is equivalent to sodium gluconate (C6H11NaO7) 21.81mg.
Within the limit of GMP(FDA，§182．6757，2000).
ChEBI: An organic sodium salt having D-gluconate as the counterion.
- Brightener for nickel iron alloy electroplating. When used alone, it can make the plating solution clear, make the plating surface bright, and make crystal fine and a great leveling. Dosage is 0.1 ~ 0.2 g/L.
- Food additives, electroplating complexing agent, water quality stabilizer, color agent in printing and dyeing industry, treatment agent for iron and steel surface.
- Used in pharmaceutical industry.
- Used as a corrosion inhibitor for circulating cooling water systems, used in electroplating and metal cleaning and used in pharmacy.
- Nutritional supplements, chelating agent and yeast food.
- In the treatment of industrial water, used as scale-corrosion inhibitor. A good compound effect with aluminum.
The calcium gluconate is added into the reaction kettle. Add sulfuric acid aqueous solution while stirring. After mixing for one hour, let it stand for a while and then get it filtered. The filter residue is CaSO4 and gets it removed. The filtrate is added into the neutralization kettle, and a proper amount of Na2CO3 aqueous solution is added to neutralize it. Finally get it through concentration, filtration and drying. Check the finished products with proper packaging.
Crystallise it from a small volume of H2O (solubility is 59g/100mL at 25o), or dissolve it in H2O and add EtOH since it is sparingly soluble in EtOH. It is insoluble in Et2O. It forms a Cu complex in alkaline solution and a complex with Fe in neutral solution. [cf p 639, Sawyer & Bagger J Am Chem Soc 81 5302 1959, Beilstein 3 I 188.]
white or off-white granular powder