Synthesis of thieno[2,3-d]pyrimidine analogues of the potent antitumor agent N-{4-[2-(2-amino-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-YL)ethyl-benzoyl}-L- glutamic acid (LY231514)

Article abstract of DOI:10.3987/com-95-7269

Several thieno[2,3-d]pyrimidine analogues of the potent antitumor agent N-{4-[2-(2-amino-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-benzoyl}-L- glutamic acid (LY231514, 7) have been prepared by two different strategies. The first involved S-alkylati