10.1002/adsc.201800817
Advanced Synthesis & Catalysis
the continuous flow - room temperature synthesis of
fine chemicals and pharmaceuticals.
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Experimental Section
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In a typical synthesis of Cu-MOF-74, a mixture of 2,5-
dihydroxyterephthalic acid (11.2 mmol) and Cu(NO3)2·3H2O
(24.6 mmol) were added over a 20:1 (v/v) solution of DMF
and 2-propanol (250 mL). The reaction vial was capped
tightly and placed in an oven at 80 °C during 18 hours. The
alkenylation reactions were performed as follows: 1 mmol of
indole or uracil, 1.2 mmol of butyl acrylate, 1 mmol of tert-
butyl hydroperoxide solution, were added to a glass vessel
containing 0.05 mmol of Pd(OAc)2, 0.1 mmol of metal
containing MOF and 1 ml of DMSO. The vials were closed
and transferred into an aluminum heating block preheated to
30 °C, the mixture was stirred and sample aliquots were taken
at different reaction times. The reaction products were
recovered and analyzed by GC-FID (see supporting
information for details).
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Acknowledgements
F.G.C. kindly acknowledges the European Commission-Horizon
2020 under the Marie Sklodowska–Curie Individual Fellowship
grant agreement number 750391 (Project acronym SINMOF) for
financial support. The XAS experiments were performed on
beamline BM26A at the European Synchrotron Radiation Facility
(ESRF), Grenoble, France. We are grateful to D. Banerjee at the
ESRF for providing assistance in using beamline. The FWO and
Spanish Ministry of Science and innovation are also acknowledged
for funding.
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