Triple (Grob) fragmentation. Retro-Mannich reactions of 1-aza-adamantane derivatives

DOI: 10.1016/0040-4039(91)80013-V

Source and publish data:

Tetrahedron Letters p. 4465 - 4468 (1991)

Update date:2022-08-04

Topics:

Authors:

Risch Risch

Langhals

Hohberg Hohberg

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Article abstract of DOI:10.1016/0040-4039(91)80013-V

The first triple (Grob) fragmentation is described. The process (mechanism) involves retro-Mannich reactions. Easily accessible 1-aza-adamantane derivatives 1 are converted to substituted 5-chloro-resorcinols 5.

Full text of DOI:10.1016/0040-4039(91)80013-V

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