Triple (Grob) fragmentation. Retro-Mannich reactions of 1-aza-adamantane derivatives

DOI: 10.1016/0040-4039(91)80013-V

Source and publish data:

Tetrahedron Letters p. 4465 - 4468 (1991)

Update date:2022-08-04

Topics:

Authors:

Risch Risch

Langhals

Hohberg Hohberg

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(91)80013-V

The first triple (Grob) fragmentation is described. The process (mechanism) involves retro-Mannich reactions. Easily accessible 1-aza-adamantane derivatives 1 are converted to substituted 5-chloro-resorcinols 5.

Full text of DOI:10.1016/0040-4039(91)80013-V

Products guided by the article

Product name:5-chloro-2,4,6-trimethyl-resorcinol

Cas No:137324-48-2

R&D Labs maybe for 137324-48-2

Hangzhou Share Chemical Co., Ltd(expird)

Contact:+86-57187093700

Address:Hang Xing Road
Changyi Xinxing Technology Development Co., Ltd.

Contact:0086-510-86651065(Time Zone:8),86651656

Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
AUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD

Contact:+86-25-86883560 15951806178

Address:14 Dayingbi, Zhujiang Rd. East, Nanjing, Jiangsu, China.
Shanghai united Scientific Co.,Ltd.

Contact:+86-21-53535353

Address:28F No.900 huaihai Road Shanghai China
Shanghai Yingrui Biopharma Co., Ltd

Contact:021-3358 8661*8003

Address:shanghai

Relevant to this article

Total synthesis of (±)-sorocenol B employing nanoparticle catalysis

Doi:10.1021/ol300800r
(2012)
Synthesis of Potent Dishevelled PDZ Domain Inhibitors Guided by Virtual Screening and NMR Studies

Doi:10.1111/j.1747-0285.2011.01295.x
(2012)
One-pot three-component synthesis of 4-aryl-3,4-dihydro-pyrimidin- 2(1H)-thiones catalyzed by Ni loaded SiO₂

Doi:10.4314/bcse.v26i1.13
(2012)
Asymmetric Synthesis of the Aromatic Fragment of Sespendole

Doi:10.1021/acs.joc.9b01597
(2019)
Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52

Doi:10.1021/jm201746x
(2012)
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents

Doi:10.1016/j.bmc.2012.03.021
(2012)

Article Doi