SYNTHESIS OF POLYHYDROXYLATED INDOLIZIDINE AND QUINOLIZIDINE COMPOUNDS -- POTENT INHIBITORS OF α-GLUCOSIDASE I

Article abstract of DOI:10.1016/S0040-4039(00)79409-3

Polyhydroxylated indolizidine 6a and quinolizidine 6b were synthesized from a common precursor, iminoheptitol 8.The target compounds are potent inhibitors of the glycoprotein trimming enzyme -- α-glucosidase I.