A novel rearrangement reaction conversion of 3-(chloromethyl)azetidin-2-ones to azetidine-3-carboxylic acid esters

DOI: 10.1016/S0040-4039(00)92310-4

Source and publish data:

Tetrahedron Letters p. 4795 - 4798 (1991)

Update date:2022-08-03

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Authors:

Bartholomew

Stocks Stocks

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Article abstract of DOI:10.1016/S0040-4039(00)92310-4

Transformation of 3-(chloromethyl)azetidin-2-ones to azetidine-3-carboxylic acid esters is described. The readily available 3-(chloromethyl)azetidin-2-ones rearranged in good yields to azetidine-3-carboxylic acid esters on treatment with alkoxides. An alternative ring opening - ring closure procedure is also identified.

Full text of DOI:10.1016/S0040-4039(00)92310-4

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