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| CAS No.: | 13463-41-7 |
|---|---|
| Name: | Zinc pyrithione |
| Molecular Structure: | |
|
|
|
| Formula: | 2(C5H4NOS).Zn |
| Molecular Weight: | 317.708 |
| Synonyms: | 2(1H)-Pyridinethione, 1-hydroxy-, zinc complex;2-Mercaptopyridine 1-oxide zinc salt;2-Pyridinethiol-1-oxide, zinc salt;AI3-62421;BC-J;Biocut ZP;Bis(1-hydroxy-2(1H)-pyridinethionato)zinc; |
| EINECS: | 236-671-3 |
| Density: | 1.782 g/cm3 (25oC) |
| Melting Point: | 262oC |
| Boiling Point: | 253.8 °C at 760 mmHg |
| Flash Point: | 107.3 °C |
| Solubility: | <0.1 g/100 mL at 21 °C in water |
| Appearance: | Fine beige granules |
| Hazard Symbols: |
 T+
|
| Risk Codes: | 24/25-26-37/38-41 |
| Safety: | 26-28-36/37/39-45 |
| Transport Information: | UN 2811 6.1/PG 2 |
| PSA: | 101.52000 |
| LogP: | 3.34050 |
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| Conditions | Yield |
|---|---|
| In water at 70℃; for 1.16667h; Product distribution / selectivity; | 99.1% |
- 100685-55-0
zinc(II) sulfate monohydrate
- 3811-73-2
2-mercaptopyridine-1-oxide sodium salt
- 13463-41-7
zinc pyrithione
| Conditions | Yield |
|---|---|
| In water | |
| In water |
- 3811-73-2
2-mercaptopyridine-1-oxide sodium salt
- 13463-41-7
zinc pyrithione
| Conditions | Yield |
|---|---|
| With acetic acid In water aq. soln. of sodium pyrithione titrated with glacial acetic acid to pH=6.5, Zn5(OH)8(NO3)2*2H2O added, suspn. stirred for 5-120 min at room temp. under ambient pressure, quenched; ppt. centrifuged, washed with ethanol and deionized water (1:1,v:v), air-dried at 65 °C for 1 d; |
- 3811-73-2
2-mercaptopyridine-1-oxide sodium salt
- 13463-41-7
zinc pyrithione
| Conditions | Yield |
|---|---|
| With acetic acid In water aq. soln. of sodium pyrithione titrated with glacial acetic acid to pH=6.5, Zn5(OH)8(CH3CO2)2*2H2O added, suspn. stirred for 5-120 min at room temp. under ambient pressure, quenched; ppt. centrifuged, washed with ethanol and deionized water (1:1,v:v), air-dried at 65 °C for 1 d; |
- 3811-73-2
2-mercaptopyridine-1-oxide sodium salt
- 13463-41-7
zinc pyrithione
| Conditions | Yield |
|---|---|
| With acetic acid In water Kinetics; aq. soln. of sodium pyrithione titrated with glacial acetic acid to pH=6.5, Zn5(OH)8(dodecylsulfate)2*2H2O added, suspn. stirred for 5-120 min at room temp. under ambient pressure, quenched; ppt. centrifuged, washed with ethanol and deionized water (1:1,v:v), air-dried at 65 °C for 1 d; |
| Conditions | Yield |
|---|---|
| In not given addn. of soln. of sodium salt of 1-hydroxypyridine-2-thione to Zn(II) nitrate soln. with stirring; pptn.; filtration; washing (water, ethanol, ether); drying in a desiccator overCaCl2; elem. anal.; |
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Chemistry
The Molecular Structure of Zinc pyrithione (CAS NO.13463-41-7):
Molecular formula :C10H8N2O2S2Zn
Molar mass: 317.70 g/mol
Nominal Mass: 316 Da
Average Mass: 317.7217 Da
Monoisotopic Mass: 315.931864 Da
EINECS: 236-671-3
IUPAC Name: zinc 1-oxidopyridine-2-thione
Product Categories: Organometallics;Heterocyclic Compounds;Classes of Metal Compounds;Transition Metal Compounds;Zn (Zinc) Compounds
Water Solubility: Insoluble (<0.1 g/100 mL at 21 ºC)
InChI
InChI=1/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2/rC10H8N2O2S2Zn/c13-11-7-3-1-5-9(11)15-17-16-10-6-2-4-8-12(10)14/h1-8H
Smiles
c1([n+](cccc1)[O-])S[Zn]Sc1[n+](cccc1)[O-]
Uses
1. Zinc pyrithione (CAS NO.13463-41-7) can be used as an antifungal and antibacterial agent. It has antibacterial properties and is effective against many pathogens from the streptococcus and staphylococcus class.It is best known in treating dandruff and seborrhoeic dermatitis.It is also used in treating psoriasis, eczema, fungus,ringworm, athletes foot, dry skin, tinea,atypical dermatitis, and vitiligo.
2.Used in paint:due to its low solubility in water (8 ppm at neutral pH), Zinc pyrithione (CAS NO.13463-41-7) is suitable for use in outdoor paints and other products that provide protection against mildew and algae. When used in latex paints and the water contains high amount of iron, a sequestering agent that will preferentially bind the iron ions is needed. Its decomposition by ultraviolet light is slow, providing years of protection even against direct sunlight.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 600mg/kg (600mg/kg) | Clinical Toxicology. Vol. 13, Pg. 1, 1978. Link to PubMed | |
| dog | LDLo | intravenous | 25mg/kg (25mg/kg) | BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966. Link to PubMed |
| guinea pig | LD50 | oral | > 2gm/kg (2000mg/kg) | Toxicology and Applied Pharmacology. Vol. 7, Pg. 425, 1965. | |
| mammal (species unspecified) | LC50 | inhalation | 140mg/m3/4H (140mg/m3) | United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0790-1035, | |
| monkey | LDLo | intravenous | 25mg/kg (25mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966. |
| mouse | LD50 | intraperitoneal | 26800ug/kg (26.8mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1067, 1974. | |
| mouse | LD50 | oral | 160mg/kg (160mg/kg) | Clinical Toxicology. Vol. 13, Pg. 1, 1978. | |
| mouse | LD50 | subcutaneous | 730mg/kg (730mg/kg) | Clinical Toxicology. Vol. 13, Pg. 1, 1978. | |
| rabbit | LD50 | skin | 100mg/kg (100mg/kg) | Yakkyoku. Pharmacy. Vol. 32, Pg. 965, 1981. | |
| rabbit | LDLo | intravenous | 10mg/kg (10mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966. |
| rat | LC50 | inhalation | 140mg/m3/4H (140mg/m3) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | National Technical Information Service. Vol. OTS0527753-1, |
| rat | LD50 | oral | 177mg/kg (177mg/kg) | Toxicology Annual. Vol. 3, Pg. 1, 1979. |
Safety Profile
Hazard Codes: 
T+
Risk Statements: 24/25-26-37/38-41
R24/25: Toxic in contact with skin and if swallowed
R26: Very Toxic by inhalation
R37/38: Irritating to respiratory system and skin
R41: Risk of serious damage to the eyes
Safety Statements: 26-28-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28: After contact with skin, wash immediately with plenty of soap-suds
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: ZH0950000
HazardClass: 6.1(b)
PackingGroup: III
Specification
Zinc pyrithione (CAS NO.13463-41-7) is also called as 1-Hydroxy-2-pyridine thione, zn salt ; 1-Hydroxypyridine-2-thione zinc ; 1-Hydroxypyridine-2-thione zinc salt ; 2-Pyridinethiol 1-oxide zinc salt ; 2-Mercaptopyridine n-oxide zinc ; 2-Mercaptopyridine n-oxide zinc salt ; 2-Mercaptopyridine-1-oxide zinc salt ; Mercaptopyridine n-oxide zinc salt .
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