Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4β-(arylamino)-4'-O- demethylpodophyllotoxins

DOI: 10.1021/jm00083a009

Source and publish data:

Journal of Medicinal Chemistry p. 866 - 871 (1992)

Update date:2022-09-26

Topics:

Authors:

Wang Wang

Liu Liu

Cheng Cheng

Lee Lee

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00083a009

The 2'-chloro derivatives of etoposide and 4β-(arylamino)-4'-O- demethylpodophyllotoxins have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causing cellular protein-lin

Full text of DOI:10.1021/jm00083a009

Products guided by the article

Product name:4β-bromo-2'-chloro-4'-O-demethyl-4-desoxypodophyllotoxin

Cas No:138261-32-2

R&D Labs maybe for 138261-32-2

SHENYANG COMEBOARD TECHNOLOGY CO., LTD

Contact:+86-24-25724626

Address:Room2210,Tianbao International Building,No.8-1 Weigong South Street,Tiexi District,Shenyang,China
Hisyntech Corporation Limited

Contact:0086-22-23410962

Address:17-201, Ningfuli, Shuishanggongyuandong road,Nankai district, Tianjin, China
Nanjing lanbai chemical Co.,Ltd.

Contact:+86-25-85499326

Address:Room 908, 9F Taiyue Building,No.285 Heyan Road
Hubei Xiangxi Chemical Industry Co.,Ltd

Contact:+86-710-3454830

Address:No.7, Daqing East Road, Xiangfan City, Hubei Province, China
QINGDAO TAOSIGN INTERNATIONAL TRADE CO.,LIMITED

Contact:+86-0532-82683616

Address:RM1402, Doublestar Seacoase 7#, No. 5 Guizhou Road, Qingdao, Shandong, China

Relevant to this article

Coordination and structural properties of encumbering 6-mesityl-2- picolinate complexes

Doi:10.1039/c2dt30585b
(2012)
A novel near-infrared-emitting cyclometalated platinum (II) complex with donor-acceptor-acceptor chromophores

Doi:10.1016/j.dyepig.2014.03.040
(2014)
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90

Doi:10.1016/j.bmcl.2012.04.121
(2012)
Docking model of the nicotinic acetylcholine receptor and nitromethylene neonicotinoid derivatives with a longer chiral substituent and their biological activities

Doi:10.1016/j.bmc.2014.12.058
(2015)
Microwave assisted catalyst-free synthesis of azaarene-substituted 3-hydroxy-2-oxindoles by the functionalization of sp³ C-H bond in methyl pyridine

Doi:10.1016/j.tetlet.2012.05.077
(2012)
Template synthesis, spectroscopic characterization and preliminary insulin-mimetic activity of oxovanadium(IV) complexes with N₂O ₂ diazadioxa macrocycles

Doi:10.1016/j.saa.2012.04.050
(2012)

Article Doi