Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4β-(arylamino)-4'-O- demethylpodophyllotoxins

DOI: 10.1021/jm00083a009

Source and publish data:

Journal of Medicinal Chemistry p. 866 - 871 (1992)

Update date:2022-09-26

Topics:

Authors:

Wang Wang

Liu Liu

Cheng Cheng

Lee Lee

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Article abstract of DOI:10.1021/jm00083a009

The 2'-chloro derivatives of etoposide and 4β-(arylamino)-4'-O- demethylpodophyllotoxins have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causing cellular protein-lin

Full text of DOI:10.1021/jm00083a009

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