Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4β-(arylamino)-4'-O- demethylpodophyllotoxins

DOI: 10.1021/jm00083a009

Source and publish data:

Journal of Medicinal Chemistry p. 866 - 871 (1992)

Update date:2022-09-26

Topics:

Authors:

Wang Wang

Liu Liu

Cheng Cheng

Lee Lee

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00083a009

The 2'-chloro derivatives of etoposide and 4β-(arylamino)-4'-O- demethylpodophyllotoxins have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causing cellular protein-lin

Full text of DOI:10.1021/jm00083a009

Products guided by the article

Product name:4β-bromo-2'-chloro-4'-O-demethyl-4-desoxypodophyllotoxin

Cas No:138261-32-2

R&D Labs maybe for 138261-32-2

Changzhou Sunlight Pharmaceutical Co., Ltd.

Contact:+86-519-83131668;83139028;83138042;83137041

Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province
Shanghai Xinda Pharmaceuticals Co., Ltd.

Contact:86-21-33692333-8008

Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China
Fujian Wanke Pharmaceutical Co., LTD.

Contact:+86-598-5026002

Address:Economic development zone,jiangle county
Binzhou Holly Pharmaceutical Co.,Ltd.

Contact:74517

Address:No.15 Dapu Road,Huangpu District Shanghai,P.R.China
Suzhou HeChuang Chemical Co.,Ltd.

Contact:+86-512-88800520

Address:No.9 Guanchao Rd,Changshu Advanced Materials Industy Park

Relevant to this article

Coordination and structural properties of encumbering 6-mesityl-2- picolinate complexes

Doi:10.1039/c2dt30585b
(2012)
A novel near-infrared-emitting cyclometalated platinum (II) complex with donor-acceptor-acceptor chromophores

Doi:10.1016/j.dyepig.2014.03.040
(2014)
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90

Doi:10.1016/j.bmcl.2012.04.121
(2012)
Docking model of the nicotinic acetylcholine receptor and nitromethylene neonicotinoid derivatives with a longer chiral substituent and their biological activities

Doi:10.1016/j.bmc.2014.12.058
(2015)
Microwave assisted catalyst-free synthesis of azaarene-substituted 3-hydroxy-2-oxindoles by the functionalization of sp³ C-H bond in methyl pyridine

Doi:10.1016/j.tetlet.2012.05.077
(2012)
Template synthesis, spectroscopic characterization and preliminary insulin-mimetic activity of oxovanadium(IV) complexes with N₂O ₂ diazadioxa macrocycles

Doi:10.1016/j.saa.2012.04.050
(2012)

Article Doi