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| CAS No.: | 298-12-4 |
|---|---|
| Name: | Glyoxylic acid |
| Article Data: | 400 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C2H2O3 |
| Molecular Weight: | 74.0361 |
| Synonyms: | Acetic acid, oxo- (9CI);Glyoxylic acid (8CI);2-oxoacetate;glyoxalate;Glyoxylic;Oxalaldehydic acid;Oxoacetic acid;Acetic acid, oxo-, sodium salt;glyoxylate;alpha-Ketoacetic acid;Formic acid, formyl-;Acetic acid, oxo;Oxoethanoic acid; |
| EINECS: | 206-058-5 |
| Density: | 1.384 g/cm3 |
| Melting Point: | -93 °C |
| Boiling Point: | 224.601 °C at 760 mmHg |
| Flash Point: | 103.914 °C |
| Solubility: | miscible with water |
| Appearance: | clear yellow solution |
| Hazard Symbols: |
 Xi, C
|
| Risk Codes: | 34-43-41 |
| Safety: | 26-36/37/39-45-37/39-24 |
| Transport Information: | UN 3265 8/PG 2 |
| PSA: | 54.37000 |
| LogP: | -0.73010 |
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- 35065-59-9
N-chloroglycine
- 298-12-4
Glyoxilic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide; sodium perchlorate In water at 298℃; Decomposition of (N-Cl)- , (N-Br)-α-amino acids, dipeptides, amines in near neutral or mild basic conditions; | 100% |
| With sodium hydroxide at 24.9℃; Rate constant; Kinetics; Thermodynamic data; other N-chloro- and N-bromo-α-amino acids; var. temp., NaOH conc. and ionic strength of solution; ΔS(excit.), ΔH(excit.); mechanism; | |
| With hydroxide In water at 24.9℃; Product distribution; |
| Conditions | Yield |
|---|---|
| With oxygen; ethylenediamine; Flavin mononucleotide In water at 15℃; under 4350.3 Torr; for 77h; glycolate oxidase, Aspergillus niger catalase, pH 8-9; | A 0.2% B 99.8% |
| Conditions | Yield |
|---|---|
| With diazoacetic acid ethyl ester; oxygen; Flavin mononucleotide In water at 5℃; under 6205.8 Torr; for 1h; Pichia Pastoris transformant MSO10 (423 IU of glycolate oxidase and 869000 IU of catalase), pH 9.25; | A 1.3% B 98.7% |
| With oxygen; 3,3-dimethyldioxirane In acetone at 32℃; Kinetics; Further Variations:; Temperatures; Oxidation; |
| Conditions | Yield |
|---|---|
| Stage #1: maleic anhydride With water In methanol; ethyl acetate at 65℃; for 0.833333h; Stage #2: With ozone In methanol; ethyl acetate at 5℃; for 3h; Solvent; Temperature; Time; | 98.3% |
| Conditions | Yield |
|---|---|
| With acetic acid; bis(2-ethyl-1H-benzimidazolinium) dichromate at 20℃; for 0.5h; | 89% |
| With acetic acid; bis(2-methyl-1H-benzimidazolinium) dichromate In ethanol at 20℃; for 0.5h; | 89% |
| With glycolate oxidase; oxygen; Flavin mononucleotide In various solvent(s) at 30℃; for 24h; Oxidation; | 80% |
- 131543-46-9
Glyoxal
- 298-12-4
Glyoxilic acid
| Conditions | Yield |
|---|---|
| Stage #1: Glyoxal With ammonium hydroxide; dihydrogen peroxide; iron(II) sulfate at 7 - 8℃; Stage #2: With sulfuric acid In ethanol at 140℃; for 3h; Stage #3: In water at 95 - 98℃; for 2h; Temperature; | 88% |
| Stage #1: Glyoxal With hydrogenchloride; nitric acid In water at 45℃; Stage #2: With oxygen; sodium nitrite In water at 43 - 60℃; under 3000.3 Torr; for 4h; Product distribution / selectivity; | 78% |
| With Tri-n-octylamine In octane at 45℃; under 1125.11 Torr; for 4h; | 57.52% |
| Conditions | Yield |
|---|---|
| 83% |
- 79866-88-9
2-chloro-2,3-dimethoxy-1,4-dioxane
- 298-12-4
Glyoxilic acid
| Conditions | Yield |
|---|---|
| With methanol; water at 20 - 25℃; for 1h; | 81% |
| Conditions | Yield |
|---|---|
| With potassium hexacyanoferrate(III) In perchloric acid; acetic acid at 50℃; Mechanism; Kinetics; Ea, ΔH(excit.), ΔS(excit.), other temperatures, other concentrations acids; | A 80% B 10% |
| With potassium bromate; thallium(III) sulfate; sulfuric acid In water; acetic acid at 40℃; for 60h; Rate constant; Mechanism; Thermodynamic data; other mineral acid; other metal ion; E(excit.), ΔH(excit.), ΔS(excit.), ΔG(excit.); | A 75% B 25% |
| With sulfuric acid; mercury(II) diacetate; bromate In water; acetic acid Mechanism; Kinetics; Thermodynamic data; effect of solvent polarity, temperature, mercury acetate on oxidation ΔH(excit.), ΔS(excit.), ΔG(excit.); |
| Conditions | Yield |
|---|---|
| With hypobromite In sodium hydroxide at 35℃; Kinetics; Mechanism; | A 80% B n/a |
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Chemistry
The Molecular Structure of Glyoxylic acid (CAS NO.298-12-4):
Empirical Formula: C2H2O3
Molecular Weight: 74.0355
IUPAC Name: oxaldehydic acid
Appearance: clear yellow solution
Nominal Mass: 74 Da
Average Mass: 74.0355 Da
Monoisotopic Mass: 74.000394 Da
Index of Refraction: 1.403
Molar Refractivity: 13.06 cm3
Molar Volume: 53.4 cm3
Surface Tension: 50.2 dyne/cm
Density: 1.384 g/cm3
Flash Point: 103.9 °C
Enthalpy of Vaporization: 50.8 kJ/mol
Boiling Point: 224.6 °C at 760 mmHg
Vapour Pressure: 0.0331 mmHg at 25°C
Storage temp: 2-8°C
Water Solubility: miscible
InChI
InChI=1/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)
Smiles
C(C=O)(O)=O
Product Categories: Pharmaceutical Intermediates
Synonyms: Formylformic Acid ; Oxoethanoic acid ; Oxoacetic acid ; Formylformic acid ; Alpha-Ketoacetic Acid ; Oxalaldehydic Acid
The conjugate base of Glyoxylic acid (CAS NO.298-12-4) is known as glyoxylate. It is an intermediate of the glyoxylate cycle, enables organisms, such as fungi, bacteria, and plants to convert fatty acids into carbohydrates .
Uses
Glyoxylic acid (CAS NO.298-12-4) is used as intermediates of spice, medicine, dyes, plastics and varnish materials,and it also used in pharmacy.
Toxicity Data With Reference
| 1. | mmo-sat 200 µg/plate ABCHA6 47,2461,83 | |||
| 2. | ims-rat LDLo:25 mg/kg | BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. 36 (1960),1937. |
Consensus Reports
Reported in EPA TSCA Inventory
Safety Profile
Hazard Codes: 
C
Xi
Risk Statements: 34-43-41
R34: Causes burns
R43: May cause sensitization by skin contact
R41: Risk of serious damage to the eyes
Safety Statements: 26-36/37/39-45-37/39-24
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S37/39: Wear suitable gloves and eye/face protection
S24: Avoid contact with skin
RIDADR: UN 3265 8/PG 2
WGK Germany: 1
RTECS: MD4550000
HazardClass: 8
PackingGroup: III
Poison by intramuscular route. Mutation data reported. A skin, eye, and mucous membrane irritant. When heated to decomposition it emits acrid smoke and fumes.