A Facile Sythesis of 1,2,3,4-Tetrahydroisoquinolines Through Cyclization of O,N-Acetals

DOI: 10.1055/s-1987-28089

Source and publish data:

Synthesis p. 824 - 827 (1987)

Update date:2022-09-26

Topics:

Authors:

Kubo, Akinori

Saito, Naoki

Kawakami, Nanko

Matsuyama, Yasuo

Miwa, Teruyo

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Article abstract of DOI:10.1055/s-1987-28089

A mild and efficient method for the synthesis of 1,2,3,4-tetrahydroisoquinolines by a modified Pictet-Spengler reaction involving Lewis acid-mediated cyclization of O,N-acetals is described.

Full text of DOI:10.1055/s-1987-28089

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