USE OF ATOM-TRANSFER RADICAL CYCLIZATIONS AS AN EFFICIENT ENTRY INTO A NEW "SEROTONERGIC" AZANORADAMANTANE

DOI: 10.1016/S0040-4039(00)60166-1

Source and publish data:

Tetrahedron Letters p. 7283 - 7286 (1992)

Update date:2022-08-05

Topics:

Authors:

Flynn, Daniel L.

Becker, Daniel P.

Nosal, Roger

Zabrowski, Daniel L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)60166-1

A route to azanoradamantanes is described which makes use of an atom-transfer radical cyclization to afford 3-azabicyclo<3.3.0>ocatanes 3A and 3B.Subsequent elaboration of exo-allylamine functionality, followed by cyclization of the endo-hydroxymethyl intermediate 9, affords the new azanoradamantanes 11 and 4.This new azatricyclic system is useful for producing serotonin 5-HT3 antagonists and 5-HT4 agonists. Key words: Azanoradamantane; 3-azabicyclo<3.3.0>octane; serotonin

Full text of DOI:10.1016/S0040-4039(00)60166-1

Products guided by the article

Product name:(3aS,4S,6aR)-5-Methylene-4-(toluene-4-sulfonylamino)-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester

Cas No:139228-13-0

R&D Labs maybe for 139228-13-0

FREEBARQUE DEVELOPMENT GROUP LIMITED

Contact:+86(0)10-5109 5335 or 5109 5345

Address:Room602,Block1-B,LINGDI OFFICE,NO.13 BEIYUAN ROAD
Win-Win chemical Co.Ltd

website:http://www.win-winchemical.com

Contact:0086-577-64498589

Address:6F, No. 396 Xingping Road, Longwan Industrial Zone, Wenzhou City, Zhejiang, 325000 P.R.China
Hangzhou Haiqiang Chemical Co.,Ltd.

Contact:+86-571-86960370

Address:Add: 5/F, Around Town North Road,No. 10, Hangzhou, Zhejiang,China
Zhejiang Chemicals Import & Export Corporation (ZHECHEM)

Contact:+86-571-87046953

Address:No. 37, Qingchun Road
Zhangjiagang Methese Composite Material Co.,

Contact:0512-85428658

Address:Shazhou Lake Technological Innovation Park,Zhangjiagang City,Jiangsu Province,China

Relevant to this article

Mg-catalyzed enantioselective benzylic C-H bond functionalization of isoindolinones: Addition to imines

Doi:10.1002/chem.201200821
(2012)
Synthesis and biological studies of a novel series of 4-(4-(1H-imidazol-1- yl)phenyl)-6-arylpyrimidin-2-amines

Doi:10.1007/s00044-013-0523-6
(2013)
Substantial refinement of the photochemical synthesis of (+)-aspicillin

Doi:10.1016/0040-4039(91)80116-N
(1991)
2,2-dimethyl-4-phenyloxazolidine and 2,2-dimethyl-4,5-diphenylimidazolidine as new chiral auxiliaries. Applications to asymmetric nitrile oxide cycloadditions

Doi:10.1016/S0957-4166(00)80018-X
(1991)
Reaction of 6-methoxybenzo[b]furan-3(2H)-one and benzo[b]thiophen-3(2H) -one with 2-aryl-1,1-dicyanoethylenes as a convenient synthetic route to substituted 2-amino-4-aryl-1,3-dicyano-7-methoxydibenzo[b,d]furans and 2-amino-4-aryl-3-cyano-4H-benzothieno[3,2-b]pyrans

Doi:10.1023/A:1024468813689
(2003)
Templated chemistry for monitoring damage and repair directly in duplex DNA

Doi:10.1039/c2cc34060g
(2012)

Article Doi