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Tricyclic Heteroaromatic Systems Containing a Bridgehead Nitrogen Atom. Part 3. Triazolopyrazolopyrimidines, Tetrazolopyrazolopyrimidines and Pyrimidopyrazolotriazines

DOI: 10.1039/P19920000239

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 239 - 244 (1992)

Update date:2022-07-30

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Authors:

Golec, Julian M. C.Golec, Julian M. C.

Scrowston, Richard M.Scrowston, Richard M.

Dunleavy, MichaelDunleavy, Michael

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Article abstract of DOI:10.1039/P19920000239

6-Phenyl-1H-pyrazolo<3,4-d>pyrimidin-3(2H)-one 16 has been prepared and converted into its 3-chloro 6, 3-thioxo 17 and 3-methylthio derivatives 9.Each of these could be converted into the 3-hydrazino derivative 3, cyclisation of which with carbon disulfide or triethyl orthoformate generated the fused 1,2,4-triazoles 23 and 20, respectively.Alternatively, the hydrazino derivative 3 gave a substituted hydrazide 26 or thiosemicarbazide 25, from which the 1,2,4-triazoles 21 and 22 respectively were obtained.The equilibrium between 3-azido-6-phenyl-1H-pyrazolo<3,4-d>pyrimidine 5 and 2-phenyl-9H-tetrazolo<1',5':1,5>pyrazolo<3,4-d>pyrimidine 27 was studied. 3-Diazo-4-methyl-6-phenyl-1H-pyrazolo<3,4-d>pyrimidine 29 was prepared by diazotisation of the corresponding amine 1 and converted into the 3-azido compound 4, which could not be cyclised to form a tetrazole.Finally, the diazo compound 29 readily formed the pyrimido<5',4':4,5>pyrazolo<3,2-c><1,2,4>triazine derivatives 32 and 33, when treated with pentane-2,4-dione and ethyl acetoacetate respectively.

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Product name:1,2-bis(5-ethoxycarbonyl-2-phenylpyrimid-4-yl)hydrazine

Cas No:139438-54-3

139438-54-3

R&D Labs maybe for 139438-54-3

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